Newbie questions about mapping multiple domain names

Hi everyone,

Excuse the lack of knowledge/experience. Is it possible to have two domain names map to two different types of websites on a single linode? If so, is there a file somewhere that performs this redirection logic?

For example:

Say I own two domain names, abc.com and def.com. I'd like for:

www.abc.com maps to my python website

www.def.com maps to my php forum

Right now, I have my php forum on another hosting plan and would love to bring that over here to not have to pay for two hostings.

Any advice would be appreciated, thanks so much!